Head and Neck Cancer Therapy from Bench to Bedside
1. Ear, Nose and Throat Department, “Saint Luke” Private Hospital, Panorama, Thessaloniki, Greece
2. Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
3. General Surgery Department, “Genisis” Private Clinic, Thessaloniki, Greece
4. Department of Maxillofacial Surgery, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
5. Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece.
Nowadays treatment of laryngeal and hypopharyngel cancer is not defined only by surgical resection. Multimodality treatment approach is considered the best approach for patients. Currently treatment includes chemotherapy, radiotherapy, and surgery. The goal with combination treatment approach is to preserve organ and function. In the past years unfortunately we had to deal with mutilating and function destroying treatment. In the past 25 years, evidences from large randomized trials presented data that organ preservation studies using sequential and concomitant radio-chemotherapy do not compromise survival when compared with surgery followed by radiotherapy. The side effects from multimodality treatment approach has to take into account and the final goal has to be not only organ preservation but also function preservation. In the current review we focus on the most common treatment options. We conclude that there is an urgent need to refine the definition of a functional organ and to refine recommendations for evaluating treatment response.
Keywords: Head and neck cancer, Concurrent radio-chemotherapy, Induction chemotherapy, Organ preservation surgery, Molecular therapy