Immunological Role of Vitamin D in Skin Diseases and Carcinoma
1. Department of Biology and Advanced Placement Biology, White Station High School, Memphis, Tennessee 38117. USA.
2. Department of Biology and Advanced Placement Biology, White Station High School, Memphis, Tennessee 38117. USA.
3. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Growing evidence attests to the vital role vitamin D plays in the dynamics of the immune system. Active 1,25(OH)2D3 binds to the vitamin D receptor (VDR) to form a ligand-activated receptor complex able to control transcription in the nucleus. We examined the various mechanisms through which vitamin D3 alters and enhances immune responses in a variety of skin conditions, as well as the pathways it activates to inhibit the progression of tumors and carcinomas. The hormone primarily elicits a change as either an inflammation modulator or cancer suppressor. Also addressed are current advancements in vitamin D treatment methods through the development of novel analogs.
Keywords: Vitamin D, Skin Diseases, Carcinoma