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Oncomedicine 2017; 2:121-125. doi:10.7150/oncm.20980 This volume Cite

Review

Malignant Pleura Mesothelioma: Clinical Perspectives

Konstantinos Grapatsas¹, Vasileios Leivaditis¹, Paul Zarogoulidis^2✉, Manfred Dahm¹, Ilias Stylianos Iliadis³, Zoi Tsilogianni⁴, Efstratios Koletsis⁵, Emmanouil Dimopoulos⁶, Ioannis Vasilikos⁷, Georgios Rizos⁸, Ektoras Gazos⁹, Nikolaos G Baikoussis¹⁰, Theodora Tsiouda¹¹, Nikolaos Barbetakis¹², Yan-Gao Man¹³, Christoforos Kosmidis¹⁴, Christophoros Kotoulas³

1. Department of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, Academic Educational Hospital, Mainz University, Kaiserslautern, Germany;
2. Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;
3. Department of Cardiac surgery, 401 General Military Hospital, Athens, Greece;
4. Department of Internal medicine, 401 General Military Hospital, Athens, Greece;
5. Department of Cardiothoracic Surgery, Medical School, University Hospital of Patras, Patras, Greece;
6. Department of Surgery, Red Cross Hospital, Saarlouis, Germany;
7. Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany;
8. Department of Oncology, 424 General Military Hospital, Thessaloniki, Greece;
9. Department of Obstetrics and Gynecology-Gynecological Oncology, University Hospital of Ioannina, Ioannina, Greece;
10. Cardiothoracic Surgery Department, General Hospital of Athens "Evangelismos," Athens, Greece;
11. Pulmonary Department-Oncology Unit, “Theageneio” Anticancer Hospital, Thessaloniki, Greece;
12. Thoracic Surgery Department, “Theageneio” Anticancer Hospital, Thessaloniki, Greece;
13. Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA;
14. Surgery Department, “Interbalkan“ European Medical Center, Thessaloniki, Greece.

✉ Corresponding author: Paul Zarogoulidis, M.D, Ph. D, Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece Fax: 00302310992424 Mobile: 00306977271974 E-mail: pzarogcom More

Abstract

Malignant pleural mesothelioma (MPM) is a primary health issue which preoccupies the health professional community worldwide. The main cause of the disease is the environmental exposure to asbestos. Because of the lack of relevant symptomatology, the disease is usually diagnosed at an advanced stage. Despite the progress in the therapeutic means, the mortality of the disease remains high. Τhe optimal approach to the disease consists of the preventive efforts to remove asbestos materials, the early diagnosis and proper early therapeutic treatment. Despite the fact that new cases of MPM are diagnosed, it is believed that the incidence of the disease is declining. In this study an overview of the epidemiology, etiology, mechanisms of pathophysiology and symptomatology of MPM is carried out.

Keywords: Malignant pleural mesothelioma, Asbestos, Epidemiology, Pathogenesis, Symptomatology.

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