Oncomedicine 2016; 1:28-34. doi:10.7150/oncm.16930
A Focus on Current Molecular Pathways in Head and Neck
1. Ear, Nose and Throat Department, “Saint Luke” Private Hospital, Panorama, Thessaloniki, Greece;
2. Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;
3. General Surgery Department, “Genisis” Private Clinic, Thessaloniki, Greece;
4. Department of Maxillofacial Surgery, University General Hospital of Alexandroupolis, Alexandroupolis, Greece;
5. Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece.
Karapantzos I, Zarogoulidis P, Karanikas M, Thomaidis V, Charalampidis C, Karapantzou C. A Focus on Current Molecular Pathways in Head and Neck. Oncomedicine 2016; 1:28-34. doi:10.7150/oncm.16930. Available from http://www.oncm.org/v01p0028.htm
Early stages of head and neck cancer require concomitant administration of chemotherapy and radiotherapy. Currently platinum, taxane and fluoruracil analogs are being administered. On the other hand, for advanced stages extensive surgery is required. During the last years, several molecular characteristics have been identified in the tissue of head and neck squamous cell carcinoma, and novel treatment options are being pursued. In this review we will elucidate these molecular pathways that could be used as a possible treatment.
Keywords: head and neck cancer, chemotherapy, radiotherapy, molecular pathways.