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Oncomedicine 2017; 2:42-51. doi:10.7150/oncm.16758 This volume Cite

Review

Base Excision Repair Manipulation in Breast Carcinoma: A Prospective Avenue to Potentiate Genome Insulting Approach

Aayushi Jain, Sunny Yadav, Mohsein Beig, Shruti Purohit, Nilesh Kumar Sharma^✉

Cancer and Translational Research Lab, Dr. D.Y Patil Biotechnology & Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India, 411033.

✉ Corresponding author: Dr. Nilesh Kumar Sharma, Cancer and Translational Research Lab, Dr. D.Y Patil Biotechnology & Bioinformatics Institute, Padmashree Dr. D. Y. Patil University, Pune, Maharashtra, India, 411033. Email: nilesh.sharmaedu.in Telephone: +91-02067919400 Fax: +91-02067919444. More

Abstract

Treating breast carcinoma gets tedious due to its invasive molecular subtypes and their various molecular genotypes. Depending upon genotype and phenotype of breast tumor types, they manipulate their survival arms in the form of DNA repair protein player including base excision repair (BER) pathway. Currently, avenues to treat breast cancer ate genotoxic drugs inflicting inter and intra-strand cross links, base modification and changes in the genome combined with inhibitors of BER pathway. This review summarizes the updated information on the relevance of BER response in breast carcinoma phenotypes and their potential therapeutic interference in the last decade.

Keywords: Base excision repair, Breast carcinoma, Chemotherapy, DNA damage response, Genotoxic Drug, Genomic instability, Radiation therapy

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