Oncomedicine 2017; 2:42-51. doi:10.7150/oncm.16758
Base Excision Repair Manipulation in Breast Carcinoma: A Prospective Avenue to Potentiate Genome Insulting Approach
Cancer and Translational Research Lab, Dr. D.Y Patil Biotechnology & Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India, 411033.
Jain A, Yadav S, Beig M, Purohit S, Sharma NK. Base Excision Repair Manipulation in Breast Carcinoma: A Prospective Avenue to Potentiate Genome Insulting Approach. Oncomedicine 2017; 2:42-51. doi:10.7150/oncm.16758. Available from http://www.oncm.org/v02p0042.htm
Treating breast carcinoma gets tedious due to its invasive molecular subtypes and their various molecular genotypes. Depending upon genotype and phenotype of breast tumor types, they manipulate their survival arms in the form of DNA repair protein player including base excision repair (BER) pathway. Currently, avenues to treat breast cancer ate genotoxic drugs inflicting inter and intra-strand cross links, base modification and changes in the genome combined with inhibitors of BER pathway. This review summarizes the updated information on the relevance of BER response in breast carcinoma phenotypes and their potential therapeutic interference in the last decade.
Keywords: Base excision repair, Breast carcinoma, Chemotherapy, DNA damage response, Genotoxic Drug, Genomic instability, Radiation therapy